Landmarks in the evolution of proteomics
1860
Friedrich Miescher identified acid and basic protein components in cell nuclei
which was mistakenly
believed to carry the genetic material
1940
Beadle and Tatum linked genes to unique protein products and formulated the one
gene - one
protein concept that has now been revised as one gene codes more than one
protein.
1953
Identification of the double-stranded structure of the DNA (Watson and Crick )
1956
Separation of proteins with a combination of paper and starch gel
two-dimensional electrophoresis
(Smithies and Poulik )
1961
Modern concept of gene expression following discovery of messenger RNA,
deciphering of genetic
code and description of theory of genetic regulatio n of protein synthesis.
1967
Protein sequencing defined and automated (Edman and Begg )
1970
Isoelectric focusing and gradient gel electrophoresis: a two -dimensional
technique (Kenrick and
Margolis )
1972
The Protein Data Bank with a collection of ten X-ray crystallographic protein
structures (Bernstein
et al )
1975
The modern form of two -dimensional electrophoresis of proteins by high
resolution separation
(O'Farrell )
1981
Use of 2-D polyacrylamide gel electrophoresis (2-D PAGE) as the core methodology
for
pharmaceutical and toxicological studies (Anderson )
1982
The concept of mapping the human proteome was put forward (Anderson)
1986
Coined the word "Genomics" by Roderick as title of the journal, which started
publication in 1987
(Kuska ).
1986
Creation of the first protein-sequence database -- SWISS-PROT -- at University
of Geneva, Switzerland
1987
Formation of the first proteomics company - Large Scale Biology Corporation
1995
Definition of the proteome (Wilkins)
1997
Publication of the first book on proteomics (Wilkins et al )
1999
The first Chair in Proteomics created at the Universiteit Utrecht, The
Netherlands. Occupant is Prof.
Ian Humphery-Smith.
2000
March
Publication of the most complete proteome of a whole organism, the bacterium
Mycoplasma
genitalium
2001
Sequencing of the human genome completed.
